Most quilters will choose either polyester or an 80/20 blend.
Just pick the one you love.
Quilt batting is essential to any quilt, providing insulation and thickness to the finished product. Two common materials used in quilting are polyester and an 80/20 cotton-polyester blend. Polyester is less expensive, lightweight, dries quickly, and is hypoallergenic. At the same time, polyester offers extra loft and resiliency.
In contrast, 80/20 cotton-polyester blend batting offers the softness and breathability of cotton. The blend combines cotton and polyester fibers to create a batting that is both warm and lightweight. In addition, the cotton content provides a soft, natural feel that is comfortable against the skin.